Senior Scientist/Team Lead role at Lambda CRO. Lead mAb upstream process dev (AMBR, 50L-200L bioreactors, QbD). 6-10 yrs exp in mammalian cell culture & bioreactor scaling in biopharma/CRO req. MSc/MTech/PhD in Biotech. #UpstreamProcessing #Biologics #Biopharma #CRO #AhmedabadJobs #ProcessDevelopment
Lead Upstream Process Development for Next-Generation Biologics
Organisational Overview
Lambda Therapeutic Research is a global full-service Clinical Research Organization (CRO) headquartered in Ahmedabad, India. With strategic facilities across North America, Europe, and Asia, we deliver comprehensive, end-to-end clinical research services to innovator, biotech, and generic pharmaceutical companies worldwide.
The Opportunity
We are seeking an accomplished and technically expert Senior Scientist or Team Lead to spearhead our Upstream Process Development activities for monoclonal antibodies (mAbs) and other biologics. In this senior role, you will lead the design, optimization, and scale-up of mammalian cell culture processes from bench-scale screening to GMP-ready production scales. You will be a key technical leader, ensuring project timelines are met with scientific rigor and innovation. If you have deep hands-on expertise in bioreactor systems, QbD, and team leadership, this is your chance to shape the upstream development pipeline for a global CRO.
Your Mission: Drive Process Innovation from Screening to GMP Scale
You will own the upstream development workflow, utilizing advanced technologies to deliver robust, scalable, and high-yielding processes for client projects.
Key Responsibilities
1. Advanced Bioreactor Process Development & Execution
- Design and execute experiments using AMBR 15 and AMBR 250 systems for high-throughput clone screening and process optimization.
- Lead hands-on operation and process development in 50L and 200L single-use bioreactors within GMP suites.
- Perform process optimization for high titre and targeted Critical Quality Attributes (CQAs).
- Scale up optimized processes and lead the execution of consistency batches at 50L and 200L scales.
2. Technical Leadership & Data Analysis
- Apply QbD (Quality by Design) principles to process development, characterization, and scale-up/down.
- Utilize DOE software (JMP, Minitab) for experimental design, data collation, presentation, and statistical analysis.
- Write and review comprehensive technical protocols, reports, and Electronic Lab Notebook (ELN) entries.
3. Laboratory Operations & Compliance
- Manage upstream tasks including autoclaving, STR/Wave bioreactor setup, instrument calibration (Vi-Cell, BGA, Cedex), and lab record maintenance.
- Ensure lab documentation and compliance, supporting tech transfer, troubleshooting deviations, and preparing development reports and CAPA documentation.
- Technically proficient in all cell culture-related aseptic operations.
4. Team Leadership (Preferred)
- Provide guidance and mentorship to junior scientists.
- Lead project planning and execution to ensure timely completion, demonstrating excellent project management skills.
Who You Are: The Ideal Candidate
You are a subject matter expert in upstream bioprocessing with a proven track record of taking processes from bench to pilot scale. You are a leader, either formally or technically, who drives projects with precision.
Your Required Qualifications:
- MSc, MTech, or PhD in Biotechnology or a closely related field.
- 6 to 10 years of direct, hands-on experience developing mAb upstream processes from mammalian cell lines within a biopharma, biotech, or relevant CRO/CDMO environment.
- Must-have hands-on experience with:
- AMBR 15 and/or AMBR 250 systems.
- Operating 50L and 200L disposable bioreactors in a development or GMP setting.
- Process analysis instruments (Vi-Cell, Blood Gas Analyzer, Cedex).
- DOE software for data analysis (JMP or Minitab).
- Strong knowledge of QbD, process characterization, and scale-up principles.
- Excellent technical writing skills for protocols and reports.
What Will Make You Stand Out (Preference):
- Prior experience in leading a team within a biopharma upstream processing unit.
- Experience in tech transfer to manufacturing partners (CMOs).
- A strong publication or presentation record in the field.
Why Build Your Career at Lambda?
1. Impact on Global Biologics Development
- Your work directly contributes to the manufacturing processes for therapeutic proteins and antibodies for clients worldwide.
- Work on diverse and challenging projects across therapeutic areas.
2. Technical Leadership & Growth
- Assume a senior technical role with ownership of critical development stages and cutting-edge equipment.
- Clear pathway for career progression into managerial or principal scientist roles.
3. Global Platform & Collaborative Science
- Be part of an international CRO with a strong scientific reputation.
- Collaborate with downstream processing, analytics, and cell line development teams on integrated projects.
Ready to Scale Up Your Career in Bioprocessing?
If you are a driven upstream processing expert looking to take on a key technical leadership role in a growing global CRO, we encourage you to apply.
- Submit your application for the Senior Scientist / Team Lead - Upstream Process Development position at Lambda Therapeutic Research.
